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Curriculum Vitae

Steven Gross

Steven Gross, Ph.D.


Department of Developmental and Cell Biology
School of Biological Sciences
University of California,Irvine
2222 Natural Sciences I Irvine,CA 92697-2300

Office: 2222 Nat. Sci I
Phone:(949) 824-3159
FAX: (949) 824-4709

Lab: 2302 Nat. Sci I
Phone: (949)824-3038


General Approach

My research is quite cross-disciplinary. The majority of biological studies have focused on biochemical or genetic understanding of biological processes, however understanding the relevant physical processes is also important. Proteins physically do things, and to understand the biology, we must start to think about proteins as machines, as well as considering their biochemical properties and genetic regulation. We will soon know the Human Genome, we already know the Drosophila and the C. Elegans Genomes, and yet are very far from understanding how proteins work, and how the exquisitely ordered structures we observe in cells, embryos, and developed organisms come about. Cytoskeletal processes such as transport are important in the creation of this order, and my lab is attempting to develop and apply physical tools to quantify transport as it occurs in living cells.


Research Experience

Postdoctoral Research

In order to investigate the in vivo function of molecular motors, I developed biophysical tools to study microtubule-based cargo transport in early drosophila embryos. Combining stalling-force measurements with nanometer-resolution particle tracking and genetic manipulations has lead to a better understanding of the regulation of bi-directional transport inside of cells. However, the regulation of this transport is apparently quite complex, and work in my lab continues to investigate these and other transport phenomena.

Graduate Research

As a graduate student I studied fast fracture, discovering that cracks move slower than predicted by theory because of the appearance of patterns of microcracks (frustrated attempted branching) that appear at a critical velocity, and dissipate energy.Towards the end of my graduate degree I became fascinated by cellular function, and started to learn more about biological organization at the cellular level. I switched to biophysics as a postdoctoral fellow at Princeton, in the lab of Dr. Steven Block.

Teaching experience



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